Abstract

Neurological diseases remain a major global healthcare challenge resulting from disturbances in the nervous system and impaired brain function due to consumption of diet or exposure to dangerous substances. One of the neurological diseases requiring global attention is psychosis. The challenge of neurodegeneration affects millions of people worldwide with substantial growth in annual estimates of affected persons. Major contributing factors to psychosis promote the generation of reactive oxygen species (ROS), mitochondrial malfunction, and systemic toxicity, especially in the blood and cerebral fluids of psychotic patients. Major symptoms of psychosis include delusions, incarnation syndrome, wildly disorganized thinking, loss of touch with reality, misidentification syndrome, hallucinations, mood disorders, delirium, aggression, anxiety, and agitation. The need to find safe therapy for neurodegenerative diseases such as psychosis influenced this study to suggest some potent, non-deleterious plants as therapy against psychosis with the widely used conventional and non-conventional drugs. Significantly, both conventional and non-conventional anti-psychotics such as clozapine, quetiapine, risperidone, quetiapine, memantine, olanzapine, pimavanserin, aripiprazole, and rivastigmine have been adopted for managing issues of psychosis because they act as serotonin-dopamine antagonists or as partial agonists to dopamine. The usage of antipsychotic medications has been dampened by various hazards or adverse effects such as death, cerebrovascular accidents, worsened motor impairment, nausea, insomnia, agitation, and metabolic and endocrine anomaly which makes their long-term prescription questionable. However, antioxidants like vitamins and nutraceuticals from plants are suggested to be prescribed as therapy against neurological diseases like psychosis based on their increased safety on users, affordability, and non-detrimental side effects. Also, medicinal plants have been adopted in ameliorating psychosis as investigation proved them to have fewer side effects on their users.